seabet app download ：April 24No.19:00-21:00
Reporting location: Information Building, New Campus, Central South University535Conference Room
Report 1
Title:A new generation of efficient storage and management model for genome-wide genetic data of hundreds of millions of samples
Report Summary:
Resolving genetic maps of complex disease phenotypes often requires processing genotype data from large-scale samples，for example packageUKBBWhole-genome genotypes of more than 400,000 subjects have been obtained (>100TB）。However，Due to the lack of efficient data structures and access algorithms，Storage of large-scale genotype data、Visit、Very difficult to manage and calculate。For this，We propose a new genotype data block structure (GenoType Block，GTB) and the corresponding high parallelismIOFrame(Genotype Blocking Compressor，GBC）。GTBis a high-speed addressable、Uniform byte encoding data structure，Can help users store and manage genotype data efficiently。At the same time，GBCThrough optimized parallel compression and decompression process，Increase the speed of data access and management，Realizing fast reading and writing of genotype data。While maintaining a high compression ratio，GBCAccess and manage compressed large-scale genotypes up to speed compared to competing methods1000More than times, performed on an ordinary workstationUKBBCalculated linkage disequilibrium ratio of genotypesPLINK V1.9The algorithm is fast56More than times.GBCProvides a friendly interactive interface and richAPIFunction library，It may become an indispensable tool in the future research of large-scale genotype data。
About the speaker
Professors introduced by Sun Yat-sen University’s “Hundred Talents Plan”，Director of the Medical Informatics Teaching and Research Office，Excellent scholar of Yixian.2009Received seabet app download a PhD from the University of Hong Kong.2013Established at the beginning of the year at the Faculty of Medicine, University of Hong KongPrecision medicineResearch team,2016Joined Zhongshan Medical College of Sun Yat-sen University full-time at the end of the year。Precision prevention and control around hereditary epidemics，Based on interdisciplinary strategy，Focus on the development of efficient disease-causing gene mapping theories and original methods，In Genetics、Bioinformatics and other fields have achieved a number of results that are highly recognized by international peers，Last corresponding authorThe paper was published inAmerican Journal of Human Genetics、Genome Biologyand other authoritative journals, total citations of papersMore than seven thousand times，The method has been written into BGI data analysis standards and many other domestic and foreign professional tutorials，Part of the results integration is realized inKGGIn series software。2021Won the Hong seabet online sports betting Kong Best Young Scholar Award.
Report 2
Title: Human microbiome research driven by high-throughput sequencing
Report Summary:
The research object of microbiomics is human symbiotic microorganisms (mainly intestinal flora)，The development of high-throughput sequencing technology and the corresponding evolution of bioinformatics technology have greatly promoted our research on human symbiotic microorganisms。What are symbiotic microorganisms？What are they doing？How they are formed？These questions are important to us as the “host”-It is crucial to understand human health and disease from the perspective of symbiotic ecosystems called microorganisms。Ding Tao’s research group applies high-throughput sequencing methods，Developing bioinformatics tools to systematically study microbiome data，Study the biological and medical significance of its indication。The research team’s early stage was based onDMMThe model proposes the human microbiome community group pattern (community type) concept，Established seabet app download a series of corresponding methods to study the dynamics and determinants of human flora。The current research focus of the research team is the determinants and assembly process of human flora，The latest research proposes that the differential input of oral and nasal microorganisms determines the diversity of lung flora based on the neutral model，Revealing the assembly process of lung flora。
About the speaker
Ding Tao，Professor of Zhongshan Medical College, Sun Yat-sen University，Doctoral Supervisor。National high-level overseas introduction of young talents (Organization Department of the Central Committee of the CPC)，Outstanding young and middle-aged talents in Sun Yat-sen University’s “Hundred Talents Plan”，Excellent scholar of Yixian.Currently the deputy director of the Microecological Medicine Branch of the Guangdong Precision Medicine Application Association、Member of the Intestinal Flora Branch of the Chinese Biophysical Society、Director of Guangdong, Hong Kong and Macao Intestinal Microecology Alliance。Internationally seabet sports betting renowned journal in the field of microbiomicsMicrobiomeandISMEReviewer。Currently hosting and participating in national natural sciences、Multiple topics including the National Key R&D Plan and Guangdong Provincial Science and Technology Plan Project。So far as the first author or corresponding authorNature、Advanced Science、Microbiome、Microbiology Spectrum、mBioPublished many research papers in high-level magazines such as 23761_23776
